N-Phenyl-N′-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl-N′-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?
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چکیده
منابع مشابه
Phenyl N-(2-methylphenyl)carbamate
In the title compound, C(14)H(13)NO(2), the aromatic rings attached to the O and N atoms make dihedral angles of 62.65 (9) and 38.28 (11)°, respectively, with the central carbamate group. The benzene rings are oriented at a dihedral angle of 39.22 (10)°. In the crystal, a very weak C-H⋯π inter-action occurs.
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In the title compound, C(16)H(16)N(2)O(2), the N'-acetyl-acetohydrazide group is approximately planar (r.m.s. deviation = 0.018 Å for the eight non-H atoms) and makes dihedral angles of 81.92 (6) and 65.19 (6)° with the terminal phenyl rings. The phenyl rings form a dihedral angle of 62.60 (7)°. In the crystal, mol-ecules are linked into sheets lying parallel to (001) by N-H⋯O and C-H⋯O hydroge...
متن کاملN-Phenyl-2-(propan-2-ylidene)hydrazinecarboxamide
In the title compound, C(10)H(13)N(3)O, the hydrazinecarboxamide N-N-C(=O)-N unit is nearly planar [maximum deviation = 0.018 (2) Å] and is inclined at a dihedral angle of 8.45 (10)° with respect to the plane of the phenyl ring. The mol-ecular structure is stabilized by an intra-molecular C-H⋯O hydrogen bond which generates an S(6) ring motif. In the crystal, mol-ecules are linked into an inver...
متن کاملPhenyl N-(4-methoxyphenyl)carbamate
The asymmetric unit of the title compound, C(14)H(13)NO(3), contains two crystallographically independent mol-ecules, in which the aromatic rings are oriented at dihedral angles of 75.64 (3) and 83.14 (3)°. An N-H⋯O hydrogen bond links the two mol-ecules. Weak intramolecular C-H⋯O inter-actions are observed in the two mol-ecules. In the crystal structure, inter-molecular N-H⋯O and C-H⋯O inter-a...
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Objective(s):According to the prevalence of neoplastic diseases, there is a deep necessity for discovery of novel anticancer drugs in the field of medicinal chemistry. In the current study, a new series ofphenylthiazole derivatives(compounds 4a-4f) was synthesizedand theiranticancer activity was assessed in vitro. Materials and Methods:All synthesized derivatives were evaluated towards three h...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2007
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2007.01.023